Analytical techniques for clinical chemistry : methods and applications / edited by Sergio Caroli, Gyula Záray.

xxx, 800 p., [8] p. of plates : ill. (some col.) ; 24 cm.Includes bibliographical references and index.pt. 1. Exploring fundamentals. Good clinical practice principles: legal background and applicability -- Clinical chemistry and the quest for quality -- Uncertainty in clinical chemistry measurements including preanalytical variables -- The role and significance of reference values in the identification and evaluation of trace elements from diet -- Sample collection, storage, and pretreatment in clinical chemistry -- Metal toxicology in clinical, forensic, and chemical pathology -- pt. 2. Selected applications. Elemental speciation in clinical sciences -- The role of analytical chemistry in the safety of drug therapy -- Analytical techniques and quality control of pharmaceuticals -- Detection of drugs in biological fluids for antidoping control -- The applicability of plasma-based techniques to biological monitoring -- Atomic spectrometric techniques for the analysis of clinical samples -- Applications of ICP-MS in human biomonitoring studies -- Molybdenum in biological samples and clinical significance of Serum Molybdenum -- Applicaion of organometallic speciation in clinical studies -- Biosensors for drug analysis -- Bioimaging of metals and proteomic studies of clinical samples by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) -- Applications of LC-MS/MS in clinical laboratory diagnostics -- Metabolomics using UPLC/HPLC-tandem mass spectrometry in diagnosis and research of inherited metabolic diseases -- Biomarkers of oxidative stress in plasma and urine -- The use of X-ray techniques in medical research -- pt. 3. Future trends. A new tool based on the use of stable isotopes and isotope pattern deconvolution (IDP)-ICP-MS for nutritional and clinical studies -- Breath analysis: analytical methodologies and clinical applications -- Proteo-metabolomic strategies in the future of drug development -- Basics in laboratory medicine: past, present, and future.

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